Kratom (Mitragyna speciosa) is a tropical evergreen tree in the coffee family. It’s native to Thailand, Myanmar, Malaysia, and other South Asian countries. The leaves, or extracts from the. The Facts on Kratom’s Long-Term Side Effects. Studies of frequent kratom users in Thailand and Malaysia suggest there may be some long-term side effects associated with the use of high doses of. Long term side effects linked with kratom. There are no as such long term effects of Kratom. One of the common side effects is the addiction. Kratom may cause addiction in many people only to a great quantity. It takes lots of time to develop addiction even in higher amounts. Another long term side effect can be tolerance. Long-Term Effects. Judging by research done on chronic, high-dose kratom users in Thailand, there are several unusual long-term effects of this drug such as: Hyperpigmentation, or darkening of facial skin. Anorexia and weight loss. Psychosis. Health Problems from Using Kratom Long Term. There have been many reported health problems associated with long-term or heavy Kratom use. A lot of these are discounted by Kratom promoters because there haven’t been any real clinical studies on Kratom. The long-term effects of kratom range both on the positive and not-so-positive side, according to medical professionals. Kratom is not marketed as a recreational drug, which could explain why a large percentage of the population has never heard of it or bothered to try it. Studies show kratom use has been on the rise in recent years, which suggests word of these leaves is spreading faster than. Short answer: The long-term risks are unknown. They are probably minor, the largest known risks are constipation and dependence (withdrawal). Kratom has not been carefully studied, so it is theoretically possible that it causes cancer or something. Long-term effects of kratom use haven’t been extensively studied, so the true extent of long-term, chronic use is not fully known. The drug has been banned in several countries, such as Thailand, due to its addiction potential, illustrating the danger of long-term repeated use. Getting Help and Treatment for Kratom Abuse. Long-term abuse of kratom is not as risk-free as many online sources make it seem. Despite the fact that kratom is not currently a DEA controlled substance and contrary to the claims of its supporters, evidence does indicate that kratom users are at risk of dependence and addiction to the drug. Severe toxic effects are rare occurrences when dealing with kratom, but there is not much information available to estimate the danger of its toxicity effects. The most harmful effects are attributed to high doses, which are 15 grams or more, and have been characterized by seizures. Long-Term Effects of Kratom Use.