Kratom has gained global recognition because of its effectiveness when it comes to treating pain and other health conditions. However, this has left a lot of people thinking: Do Drug Interactions Happen with Kratom? Some people try combining drugs to demonstrate their effectiveness. Others believe that in so doing, they will be able to boost […] Kratom, the original name used in Thailand, is a member of the Rubiaceae family. Other members of the Rubiaceae family include coffee and gardenia. The leaves of kratom are consumed either by chewing, or by drying and smoking, putting into capsules, tablets or extract, or by boiling into a tea. The potential dangers of Kratom are not fully understood. On its own, overdose is rare but when combined with alcohol or drugs, dangerous side effects can occur. While technically “legal” in most states across America, it is still a concerning drug with a potential for abuse, dependency, and even addiction. Three dangers of kratom include: 1. People like to experiment with new herbs, and kratom is no different. However, it does have significant physiological effects and there is a potential for kratom drug interactions. We decided to write this article to help you avoid those harmful interactions. Kratom can cause effects similar to both opioids and stimulants. Two compounds in kratom leaves, mitragynine and 7-α-hydroxymitragynine, interact with opioid receptors in the brain, producing sedation, pleasure, and decreased pain, especially when users consume large amounts of the plant. Mitragynine also interacts with other receptor systems. Harmful kratom drug interactions may occur. For safety reasons, the consumer should be aware of these drug interactions. Some of the drug interactions include the following: Combining kratom with prescription opiates. One might get tempted to combine kratom and the prescription opiates, to increase the pain relief that they feel. The point does still stands, though, that just because something is natural, doesn't make it impossible for it to be a part of harmful drug interactions - take St John's Wort, for example. Maybe kratom doesn't interact with any major drugs, I don't know. Kratom drug interactions and the safety of kratom when combined with other substances. Although the research is still limited when it comes to kratom and kratom drug interactions, there are numerous reasons to believe kratom should only be taken by itself, and never mixed with any other substance. Specifically opioids, alcohol, and benzodiazepines. Kratom is a tree. Learn more about Kratom uses, benefits, side effects, interactions, safety concerns, and effectiveness. Learn more about Kratom uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Kratom.