She was experiencing severe foot pain from planter facitis. I told her about Kratom. She was interested so I made enough capsules to last a week. This is day 5 of her taking Kratom. I can only say that 90% of her pain is gone and what pain is still there is manageable. She has said that she had no interaction with the Kratom and antidepressants. Learn more about Kratom uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Kratom I've taken zoloft and kratom at the same time many times. I've been using this Kratom powder. I've heard there could be problems mixing the Kratom with an SSRI. Mixing kratom with other psychoactive substances can be highly dangerous, as they may have negative interactions with each other. Seizures. However, in the US, kratom can […] A warning for those on zoloft/ssris. Too much dopamine is a bad thing, so throttle back on the kratom, or the zoloft. I take a half dose of zoloft 100mg and go crazy on the kratom. Also when you first start an ssri it is a bit of a shock to your system, you can feel anxious and other things. Those subside after several days. The same day I ran out of Zoloft I also received my order of Kratom 'Maeng Da Super RX' alkaloidal extract in the mail. I have been taking medium-high doses of kratom twice a day for the past few days and have barely noticed ANY of the usual SSRI withdrawal symptoms. If you Google kratom and zoloft or kratom and ssri you'll get tons of information. Go check it out! I scanned though some posts and there are a lot of people who mix kratom with ssri's without any problems. The only thing iv'e heard of to not mix with kratom is MAOI'S. Everyone's different when it comes to mixing drugs. Many say that replacing a SSRI with kratom is just like replacing one anti-depressant with another. However, this is not true. Depending on much kratom you take during your SSRI taper (where you are slowly reducing and ultimately giving up your SSRI consumption), you can benefit from kratom’s relaxing and soothing effects. Kratom, the original name used in Thailand, is a member of the Rubiaceae family. Other members of the Rubiaceae family include coffee and gardenia. The leaves of kratom are consumed either by chewing, or by drying and smoking, putting into capsules, tablets or extract, or by boiling into a tea. My normal prescription of 200mg zoloft for ocd, 1mg klonopin 4x daily as needed, neurontin 100mg 3x day as needed. On this day I took my zoloft, and half a klonopin when I woke up at around 11am so I wouldn't get any negative effects from not taking any, but also I wanted to take as little as possible so I could judge the experience accurately.